Multi-Gene Methylation Detection Kit for Human Colorectal Cancer

This kit is intended for the in vitro qualitative detection of the methylation of Septin9, BCAT1, IKZF1, and VAV3 genes in human plasma samples.

It is suitable for patients with positive fecal occult blood or other symptoms (such as changes in bowel habits, changes in stool shape, chronic constipation, tenesmus, etc.)  or patients who have been diagnosed and recommended by clinicians for further examinations. It is used for clinical auxiliary diagnosis of colorectal cancer, serving for clinician's reference only. A positive detection result cannot be used as evidence for the diagnosis of colorectal cancer. Clinical diagnostic colonoscopy and pathology results should be taken into account to confirm the diagnosis. Similarly, a negative result cannot be used to rule out the possibility of colorectal cancer. This kit is also intended for the risk assessment of recurrence and metastasis after radical resection of colorectal cancer. A positive detection result indicates a high risk of recurrence and metastasis, but it cannot be used as a basis for diagnosis. A comprehensive evaluation based on the patient's clinical situation is necessary. Also, a negative detection result cannot be used to rule out the possibility of recurrence and metastasis. It is already known that positive methylation results of the above genes have been observed in pregnant women and patients with certain diseases such as digestive tract inflammation, non-rheumatoid arthritis, and non-intestinal cancer. With the purpose of preoperative auxiliary diagnosis, the kit should be used when the detection and evaluation have not yet been conducted for patients who have previously received surgery, drug therapy, neoadjuvant therapy and other anti-tumor treatments.